HMGIC (High mobility group protein isoform I-C)

Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas.

Recently, the high mobility group protein gene HMGIC was identified as the chromosome 12q15 target gene in a variety of benign solid tumors. Here, we report that the recombinational repair gene RAD51B on chromosome 14q23-24 is the preferential translocation partner of HMGIC in uterine leiomyomas. The pathogenetically critical sequences seem to reside in the last coding exon of a novel RAD51B is...

HMGIY (high mobility group protein (non histone chromosomal) isoform I and Y)

Pygmy mouse gene mutation protects against obesity.

Of the four spontaneous mouse mutations resulting in impaired growth, the pygmy mouse is extraordinary because it has no aberrations in pathways involving growth hormone or insulin-like growth factors. The pygmy phenotype is caused by a defect in the HMGI-C gene, which is a member of the HMGI family of proteins (1, 2). HMGI proteins belong to a general class of high mobility group (HMG) DNA bin...

Activation of C-kinase eta through its cholesterol-3-sulfate-dependent phosphorylation by casein kinase I in vitro.

The physiological correlation between casein kinase I (CK-I) and an isoform eta of protein kinase C (C-kinase eta) was investigated in vitro, since it has been reported that (i) cholesterol-3-sulfate (CH-3S) effectively activates C-kinase eta rather than the other isoforms (C-kinase epsilon and C-kinase delta) in vitro; and (ii) CK-I efficiently phosphorylates CH-3S-binding proteins, such as hi...

Neuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein

The pathogenesis of autism spectrum disorder (ASD) likely involves genetic and environmental factors, impacting the complex neurodevelopmental and behavioral abnormalities of the disorder. Scientific researches emerging within the past two decades suggest that immune dysfunction and inflammation have pathogenic influences through different mechanisms, all leading to both a chronic state of low ...